If you push it, you can make it in one day. I made it in a Ryder truck from Phoenix to Memphis in a single shot. It was a long ass day, but I made it. Gives you an additional day to adjust to the altitude. I like to arrive in the general vicinity and take my first and last day in a hotel. Arrive to go grocery shopping, get a good nights rest and make sure there are no issues like closures due to Covid, forest fires, mudslides, etc. On my last day I drive out, stay in, shower (at least twice) eat a big meal and prep for travel home.
I have a trip coming up in 5 weeks to Creede/Ouray/Silverton/Montrose/Moab. Driving straight through to Creede (Alamosa has more hotels) then 3 days on trails, a single day hotel, 3 more days on a different trail and arrive in Moab. Stay 2 days and drive home.
As for where, scour the map and videos at trailsoffroad.com. Video, waypoint description, camping locations of all of the trails around the Ouray/Silerton/Lake CIty/Telluride area.